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Diterpenoid biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
copalyl_diphosphate + H2O <=> nezukol + diphosphate 4.2.3.183 nezukol synthase
–
sugiol + reduced_flavodoxin + O2 <=> 11-hydroxysugiol + flavin + H2O 1.14.14.60 ferruginol monooxygenase
–
abieta-8,11,13-triene + reduced_flavodoxin + O2 <=> ferruginol + flavin + H2O 1.14.14.175 ferruginol synthase
–
ent-kaur-16-en-19-ol + reduced_flavodoxin + O2 <=> ent-kaur-16-en-19-al + flavin + 2 H2O 1.14.14.86 ent-kaurene monooxygenase
–
ferruginol + reduced_flavodoxin + O2 <=> 11-hydroxyferruginol + flavin + H2O 1.14.14.60 ferruginol monooxygenase
–
3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NAD+ <=> momilactone_A + NADH + H+ 1.1.1.295 momilactone-A synthase
–
gibberellin_a20 + 2-oxoglutarate + O2 <=> gibberellin_1 + succinate + CO2 1.14.11.15 gibberellin 3beta-dioxygenase
–
taxa-4(20),11-dien-5alpha-ol + acetyl-CoA <=> taxa-4(20),11-dien-5alpha-yl_acetate + CoA 2.3.1.162 taxadien-5alpha-ol O-acetyltransferase
–
copalyl_diphosphate <=> isopimara-7,15-diene + diphosphate 4.2.3.44 isopimara-7,15-diene synthase
–
(E,E)-geranyllinalool + reduced_flavodoxin + O2 <=> (E,E)-4,8,12-trimethyltrideca-1,3,7,11-tetraene + flavin + 3-buten-2-one + 2 H2O 1.14.14.58 trimethyltridecatetraene synthase
–
(13E)-8alpha-hydroxylabd-13-en-15-yl_diphosphate <=> geranylgeranyl_diphosphate + H2O 4.2.1.133 copal-8-ol diphosphate hydratase
4.2.3.133 alpha-copaene synthase
–
–
ent-cassa-12,15-diene + O2 + reduced_flavodoxin <=> ent-11beta-hydroxycassa-12,15-diene + flavin + H2O 1.14.14.112 ent-cassa-12,15-diene 11-hydroxylase
–
ent-kaurene <=> Veatchine not assigned
 –
copalyl_diphosphate <=> palustradiene + diphosphate 4.2.3
4.2.3.32 levopimaradiene synthase
–
–
abieta-8(14),12-diene <=> levopimaradienol 1.14.13
–
ent-sandaracopimara-8(14),15-diene + reduced_flavodoxin + O2 <=> ent-sandaracopimaradien-3beta-ol + flavin + H2O 1.14.14.70 ent-sandaracopimaradiene 3-hydroxylase
–
9beta-pimara-7,15-dien-19-oate <=> 3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide not assigned
 –
abietadienal + reduced_flavodoxin + O2 <=> abietic_acid + flavin + H2O 1.14.14.145 abieta-7,13-dien-18-ol hydroxylase
–
copalyl_diphosphate <=> miltiradiene + diphosphate 4.2.3.131 miltiradiene synthase
–
ent-7alpha-hydroxykaur-16-en-19-oate + reduced_flavodoxin + O2 <=> gibberellin_A12_aldehyde + flavin + 2 H2O 1.14.14.107 ent-kaurenoic acid monooxygenase
–
copalyl_diphosphate <=> diphosphate + abieta-7,13-diene 4.2.3.18 abieta-7,13-diene synthase
–
(13E)-8alpha-hydroxylabd-13-en-15-yl_diphosphate + H2O <=> sclareol + diphosphate 4.2.3.141 sclareol synthase
4.2.3.B31
–
–
Palustradienal <=> Palustric_acid not assigned
 –
gibberellin_A51 <=> Gibberellin_A51-catabolite 1.14.11.13 gibberellin 2beta-dioxygenase
–
ent-isokaurene + O2 + reduced_flavodoxin <=> ent-isokauren-2beta-ol + flavin + H2O 1.14.14.76 ent-isokaurene C2/C3-hydroxylase
–
geranylgeranyl_diphosphate <=> fusicocca-2,10(14)-diene + diphosphate 4.2.3.43 fusicocca-2,10(14)-diene synthase
–
geranylgeranyl_diphosphate <=> Cembrene not assigned
 –
ent-copalyl_diphosphate <=> ent-cassa-12,15-diene + diphosphate 4.2.3.28 ent-cassa-12,15-diene synthase
–
gibberellin_a37 <=> Gibberellin_A36 not assigned
 –
geranylgeranyl_diphosphate <=> ent-copalyl_diphosphate 5.5.1.12 copalyl diphosphate synthase
5.5.1.13 ent-copalyl diphosphate synthase
5.5.1.14 syn-copalyl-diphosphate synthase
–
–
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geranylgeraniol + reduced_flavodoxin + O2 <=> 18-hydroxygeranylgeraniol + flavin + H2O 1.14.14.146 geranylgeraniol 18-hydroxylase
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ferruginol + reduced_flavodoxin + O2 <=> salviol + flavin + H2O 1.14.14.62 salviol synthase
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ent-copalyl_diphosphate <=> diphosphate + ent-isokaurene 4.2.3.103 ent-isokaurene synthase
4.2.3.19 ent-kaurene synthase
–
–
11-hydroxyferruginol + reduced_flavodoxin + O2 <=> 11-hydroxysugiol + flavin + H2O 1.14.14.65 sugiol synthase
–
ent-7alpha-hydroxykaur-16-en-19-oate + reduced_flavodoxin + O2 <=> 6beta,7beta-Dihydroxykaurenoic_acid + flavin + H2O 1.14.14.107 ent-kaurenoic acid monooxygenase
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copalyl_diphosphate <=> stemar-13-ene + diphosphate 4.2.3.33 stemar-13-ene synthase
–
gibberellin_A34 <=> Gibberellin_A34-catabolite 1.14.11.13 gibberellin 2beta-dioxygenase
–
9beta-pimara-7,15-diene + reduced_flavodoxin + O2 <=> 9beta-pimara-7,15-diene-3beta-ol + flavin + H2O 1.14.14.68 syn-pimaradiene 3-monooxygenase
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taxa-4(20),11-dien-5alpha-ol + reduced_flavodoxin + O2 <=> taxa-4(20),11-dien-5alpha,13alpha-diol + flavin + H2O 1.14.14.106 taxane 13alpha-hydroxylase
–
gibberellin_a20 <=> gibberellin_a5 1.14.11
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isopimaradienal <=> (13S)-pimara-7,15-dien-18-oate not assigned
 –
ent-cassa-12,15-diene + 3 reduced_flavodoxin + 3 O2 <=> ent-3beta-hydroxycassa-12,15-dien-2-one + 3 flavin + 4 H2O 1.14.14.69 ent-cassadiene hydroxylase
–
taxa-4,11-diene + reduced_flavodoxin + O2 <=> taxa-4(20),11-dien-5alpha-ol + flavin + H2O 1.14.14.176 taxadiene 5alpha-hydroxylase
–
N-debenzoyl-(3''-RS)-taxol + benzoyl-CoA <=> H+ + paclitaxel + CoA 2.3.1
–
Gibberellin_A53 + O2 + 2-oxoglutarate <=> gibberellin_44 + CO2 + succinate 1.14.11
1.14.11.12 gibberellin-44 dioxygenase
–
–
ent-kaurene <=> Aconitine not assigned
 –
taxa-4(20),11-dien-5alpha,13alpha-diol <=> 10-deacetyl-2-debenzoylbaccatin_III not assigned
 –
ent-kaur-16-en-19-oate + reduced_flavodoxin + O2 <=> ent-7alpha-hydroxykaur-16-en-19-oate + flavin + H2O 1.14.14.107 ent-kaurenoic acid monooxygenase
–
neoabietadiene <=> Neoabietinol 1.14.13
–
ent-isokauren-2beta-ol + O2 + reduced_flavodoxin <=> ent-isokaurene-2beta,3beta-diol + flavin + H2O 1.14.14.76 ent-isokaurene C2/C3-hydroxylase
–
Gibberellin_A29 <=> Gibberellin_A29-catabolite 1.14.11.13 gibberellin 2beta-dioxygenase
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copalyl_diphosphate + H2O <=> aphidicolan-16beta-ol + diphosphate 4.2.3.42 aphidicolan-16beta-ol synthase
–
palustradiene <=> Palustradienol 1.14.13
–
(13E)-8alpha-hydroxylabd-13-en-15-yl_diphosphate <=> cis-abienol + diphosphate 4.2.3.140 cis-abienol synthase
–
Gibberellin_A14_aldehyde <=> Gibberellin_A14 not assigned
 –
gibberellin_a15 <=> gibberellin_44 not assigned
 –
Palustradienol <=> Palustradienal 1.14.13
–
copalyl_diphosphate <=> pimara-8(14),15-diene + diphosphate 4.2.3.147 pimaradiene synthase
–
taxa-4(20),11-dien-5alpha-yl_acetate + reduced_flavodoxin + O2 <=> 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl_acetate + flavin + H2O 1.14.14.105 taxane 10beta-hydroxylase
–
2beta-hydroxygibberellin_1 <=> Gibberellin_A8-catabolite 1.14.11.13 gibberellin 2beta-dioxygenase
–
ferruginol + 2 reduced_flavodoxin + 2 O2 <=> sugiol + 2 flavin + 3 H2O 1.14.14.65 sugiol synthase
–
geranylgeranyl_diphosphate <=> diphosphate + taxa-4,11-diene 4.2.3.17 taxadiene synthase
–
11-hydroxyferruginol + 3 reduced_flavodoxin + 3 O2 <=> carnosic_acid + 3 flavin + 4 H2O 1.14.14.61 carnosic acid synthase
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Gibberellin_A24 + 2-oxoglutarate + O2 <=> Gibberellin_A36 + succinate + CO2 1.14.11
–
3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NADP+ <=> momilactone_A + NADPH + H+ 1.1.1.295 momilactone-A synthase
–
11-hydroxysugiol + reduced_flavodoxin + O2 <=> 11,20-dihydroxysugiol + flavin + H2O 1.14.14.67 11-hydroxysugiol 20-monooxygenase
–
abieta-7,13-diene + reduced_flavodoxin + O2 <=> abietadienol + flavin + H2O 1.14.14.144 abieta-7,13-diene hydroxylase
–
10-deacetylbaccatin_III + acetyl-CoA <=> baccatin_III + CoA 2.3.1.167 10-deacetylbaccatin III 10-O-acetyltransferase
–
gibberellin_A12_aldehyde <=> Gibberellin_A14_aldehyde not assigned
 –
baccatin_III + (3R)-3-amino-3-phenylpropanoyl-CoA <=> 3''-N-Debenzoyl-2''-deoxytaxol + CoA 2.3.2
–
gibberellin_A12_aldehyde <=> Gibberellin_A53_aldehyde not assigned
 –
gibberellin_a9 <=> gibberellin_a20 not assigned
 –
geranylgeranyl_diphosphate + H2O <=> (E,E)-geranyllinalool + diphosphate 4.2.3.144 geranyllinalool synthase
4.2.3.48 (3S,6E)-nerolidol synthase
4.2.3.49 (3R,6E)-nerolidol synthase
–
–
–
gibberellin_A12 <=> Gibberellin_A14 not assigned
 –
3''-N-Debenzoyl-2''-deoxytaxol + reduced_acceptor + O2 <=> 3''-N-Debenzoyltaxol + acceptor + H2O 1.14
–
gibberellin_A12_aldehyde + reduced_flavodoxin + O2 <=> gibberellin_A12 + flavin + H2O 1.14.14.107 ent-kaurenoic acid monooxygenase
–
copalyl_diphosphate <=> neoabietadiene + diphosphate 4.2.3.132 neoabietadiene synthase
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isopimara-7,15-diene <=> isopimara-7,15-dienol 1.14.13
–
gibberellin_a20 + 2-oxoglutarate + O2 <=> Gibberellin_A29 + succinate + CO2 1.14.11
1.14.11.13 gibberellin 2beta-dioxygenase
–
–
abietadienal + H2O + NAD+ <=> abietic_acid + NADH + H+ 1.2.1.74 abieta-7,13-dien-18-al dehydrogenase
–
9beta-pimara-7,15-diene + 3 O2 + 3 reduced_flavodoxin <=> 9beta-pimara-7,15-dien-19-oate + 3 flavin + 4 H2O 1.14.14.111 9beta-pimara-7,15-diene oxidase
–
abietadienol + reduced_flavodoxin + O2 <=> abietadienal + flavin + H2O 1.14.14.145 abieta-7,13-dien-18-ol hydroxylase
–
isopimara-7,15-dienol <=> isopimaradienal 1.14.13
–
gibberellin_a9 + 2-oxoglutarate + O2 <=> gibberellin_A51 + succinate + CO2 1.14.11
1.14.11.13 gibberellin 2beta-dioxygenase
–
–
geranylgeranyl_diphosphate <=> ent-copalyl_diphosphate 5.5.1.12 copalyl diphosphate synthase
5.5.1.13 ent-copalyl diphosphate synthase
5.5.1.14 syn-copalyl-diphosphate synthase
–
–
–
ent-kaur-16-ene + reduced_flavodoxin + O2 <=> ent-kaur-16-en-19-ol + flavin + H2O 1.14.14.86 ent-kaurene monooxygenase
–
Gibberellin_A14 <=> gibberellin_a37 not assigned
 –
ent-sandaracopimaradien-3beta-ol + reduced_flavodoxin + O2 <=> oryzalexin_D + flavin + H2O 1.14.14.123 oryzalexin D synthase
–
Gibberellin_A24 <=> Gibberellin_19 not assigned
 –
Gibberellin_A24 <=> gibberellin_a9 + CO2 1.14.11.12 gibberellin-44 dioxygenase
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10beta-hydroxytaxa-4(20),11-dien-5alpha-yl_acetate + O2 + NADPH + H+ <=> 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl_acetate + NADP+ + H2O 1.14.13.146 taxoid 14beta-hydroxylase
–
miltiradiene <=> abieta-8,11,13-triene not assigned
 –
copalyl_diphosphate <=> abieta-8(14),12-diene + diphosphate 4.2.3.32 levopimaradiene synthase
–
Gibberellin_A36 <=> gibberellin_a4 + CO2 not assigned
 –
gibberellin_A12 + O2 + 2-oxoglutarate <=> gibberellin_a15 + CO2 + succinate 1.14.11
1.14.11.12 gibberellin-44 dioxygenase
–
–
geranylgeranyl_diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphate 3.1.7.10 (13E)-labda-7,13-dien-15-ol synthase
–
11-hydroxyferruginol + reduced_flavodoxin + O2 <=> 11,20-dihydroxyferruginol + flavin + H2O 1.14.14.67 11-hydroxysugiol 20-monooxygenase
–
gibberellin_A12 <=> Gibberellin_A53 not assigned
 –
stemod-13(17)-ene + 3 O2 + 3 reduced_flavodoxin <=> syn-stemoden-19-oate + 3 flavin + 4 H2O 1.14.14.111 9beta-pimara-7,15-diene oxidase
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ent-sandaracopimaradien-3beta-ol + reduced_flavodoxin + O2 <=> oryzalexin_E + flavin + H2O 1.14.14.122 oryzalexin E synthase
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gibberellin_a15 + 2-oxoglutarate + O2 <=> Gibberellin_A24 + succinate + CO2 + H2O 1.14.11.12 gibberellin-44 dioxygenase
1.14.20
–
–
gibberellin_1 + 2-oxoglutarate + O2 <=> 2beta-hydroxygibberellin_1 + succinate + CO2 1.14.11.13 gibberellin 2beta-dioxygenase
–
copalyl_diphosphate <=> 9beta-pimara-7,15-diene + diphosphate 4.2.3.35 syn-pimara-7,15-diene synthase
–
ferruginol + 3 reduced_flavodoxin + 3 O2 <=> pisiferic_acid + 3 flavin + 4 H2O 1.14.14.61 carnosic acid synthase
–
gibberellin_GA7 <=> gibberellin not assigned
 –
copalyl_diphosphate <=> stemod-13(17)-ene + diphosphate 4.2.3.33 stemar-13-ene synthase
4.2.3.34 stemod-13(17)-ene synthase
–
–
gibberellin_a15 <=> gibberellin_a37 not assigned
 –
ent-copalyl_diphosphate <=> ent-sandaracopimara-8(14),15-diene + diphosphate 4.2.3.19 ent-kaurene synthase
4.2.3.29 ent-sandaracopimaradiene synthase
–
–
ent-kaur-16-en-19-al + reduced_flavodoxin + O2 <=> ent-kaur-16-en-19-oate + flavin + H2O 1.14.14.86 ent-kaurene monooxygenase
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copalyl_diphosphate + H2O <=> phyllocladan-16alpha-ol + diphosphate 4.2.3.45 phyllocladan-16alpha-ol synthase
–
geranylgeranyl_diphosphate + H2O <=> geranylgeraniol + diphosphate 3.1.7.1 prenyl-diphosphatase
3.1.7.5 geranylgeranyl diphosphate diphosphatase
–
–
gibberellin_a4 <=> gibberellin_GA7 not assigned
 –
gibberellin_a9 + 2-oxoglutarate + O2 <=> gibberellin_a4 + succinate + CO2 1.14.11
1.14.11.15 gibberellin 3beta-dioxygenase
–
–
aphidicolan-16beta-ol <=> aphidicolin not assigned
 –
ent-8alpha-hydroxylabd-13-en-15-yl_diphosphate <=> ent-13-epi-manoyl_oxide + diphosphate 4.2.3.186 ent-13-epi-manoyl oxide synthase
–
gibberellin_a4 <=> gibberellin_1 not assigned
 –
10-deacetyl-2-debenzoylbaccatin_III + benzoyl-CoA <=> 10-deacetylbaccatin_III + CoA 2.3.1.166 2alpha-hydroxytaxane 2-O-benzoyltransferase
–
geranylgeranyl_diphosphate <=> ent-copalyl_diphosphate 5.5.1.12 copalyl diphosphate synthase
5.5.1.13 ent-copalyl diphosphate synthase
5.5.1.14 syn-copalyl-diphosphate synthase
–
–
–
Neoabietal <=> Neoabietic_acid not assigned
 –
levopimaradienal <=> Levopimaric_acid not assigned
 –
2,3-Dehydro-gibberellin_A9 <=> gibberellin_GA7 1.14.11
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copalyl_diphosphate <=> syn-labda-8(17),12E,14-triene + diphosphate 4.2.3.99 labdatriene synthase
–
gibberellin_a9 <=> 2,3-Dehydro-gibberellin_A9 1.14.11
–
gibberellin_a4 + 2-oxoglutarate + O2 <=> gibberellin_A34 + succinate + CO2 1.14.11
1.14.11.13 gibberellin 2beta-dioxygenase
–
–
ent-copalyl_diphosphate <=> ent-pimara-8(14),15-diene + diphosphate 4.2.3.30 ent-pimara-8(14),15-diene synthase
–
geranylgeranyl_diphosphate <=> clerodienyl_diphosphate 5.5.1.28 (-)-kolavenyl diphosphate synthase
5.5.1.B7
–
–
Gibberellin_19 + O2 + 2-oxoglutarate <=> H+ + gibberellin_a20 + CO2 + succinate 1.14.11
1.14.11.12 gibberellin-44 dioxygenase
–
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levopimaradienol <=> levopimaradienal 1.14.13
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Neoabietinol <=> Neoabietal 1.14.13
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ent-8alpha-hydroxylabd-13-en-15-yl_diphosphate <=> geranylgeranyl_diphosphate + H2O 4.2.1.173 ent-8alpha-hydroxylabd-13-en-15-yl diphosphate synthase
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ent-copalyl_diphosphate <=> diphosphate + ent-kaurene 4.2.3.19 ent-kaurene synthase
5.5.1.13 ent-copalyl diphosphate synthase
–
–
Gibberellin_A53_aldehyde <=> Gibberellin_A53 not assigned
 –
gibberellin_a5 <=> gibberellin 1.14.11
–
10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl_acetate <=> 10-deacetyl-2-debenzoylbaccatin_III not assigned
 –
geranylgeranyl_diphosphate <=> diphosphate + casbene 4.2.3.8 casbene synthase
–
gibberellin_44 + 2-oxoglutarate + O2 <=> Gibberellin_19 + succinate + CO2 + H2O 1.14.11.12 gibberellin-44 dioxygenase
–

Visualization of the pathway